2014 Identification of Effective Doses in Binary Mixtures

Proc. Int. Conference on Information Technologies (InfoTech-2014). St. Constantine and Elena resort, Bulgaria, sept.18-20, 2014, pp.316-
324. ISSN 1314-1023.
Abstract. This paper proposes a model for estimation of the dose-response relationship of a two-component mixture. It puts forth a method for determination of combinations of active binary agents. А modified logistic function is used as analytic model for determining the dose-effect. Isobolographic curve is approximated by an exponential function. The identification procedure is based on the cyclic coordinate descent method. The approach is implemented in the computer program KORELIA-Dynamics.