Targeted drug delivery: concepts and design

"This authoritative volume explores the fundamental concepts and numerous applications of targeted delivery of drugs to the body. This compilation has been divided into eight sections comprised of the basic principles of drug targeting, disease and organ/organelle-based targeting, passive and active targeting strategies, and various advanced drug delivery tools such as functionalized lipidic, polymeric and inorganic nanocarriers. Together, the twenty-three chapters cover a wide range of topics in the field, including tumor and hepatic targeting, polymer-drug conjugates, nanoemulsion, physical"--Publisher's description.;Part I: Targeted drug delivery: basic concepts and advances. Targeted drug delivery systems: strategies and challenges -- Part II: Disease-based targeting. Recent advances in tumor targeting approaches -- Infectious diseases: need for targeted drug delivery -- Part III: Organ-based targeting. Image-guided delivery of therapeutics to the brain -- Inhalation therapy for pulmonary tuberculosis -- Hepatic targeting: physiological basis and design strategy -- Part IV: Cell- and cell organelle-based targeting. Targeted drug delivery to the mitochondria -- Targeted delivery of nucleic acid therapeutics via nonviral vectors -- Mucosal vaccine delivery and M cell targeting -- Part V: Physicochemical approaches for targeting -- Stimuli responsive carriers: magnetically, thermally and pH assisted drug delivery -- Prodrug conjugate strategies in targeted anticancer drug delivery systems -- Polymer-drug conjugates for targeted drug delivery -- Part VI: Carrier-based approaches for targeted drug delivery. Functionalized lipid particulates in targeted drug delivery -- Nanoemulsion in drug targeting -- Multifunctional polymeric nano-carriers in targeted drug delivery -- Polymeric micelles in targeted drug delivery -- Dendritic polymers in targeted drug delivery -- Inorganic nanoparticles in targeted drug delivery and imaging -- Carbon-based nanomaterials for targeted drug delivery and imaging -- Part VII: Advanced characterization techniques for nanocarriers. Physical and biophysical characteristics of nanoparticles: potential impact on targeted drug delivery -- In vivo imaging techniques of the nanocarriers used for targeted drug delivery -- Part VIII: Nanotoxicology and regulatory issues -- Evaluation of lung toxicity of biodegradable nanoparticles -- Nanotoxicology: contemporary issues and future directions.